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Cardiovascular Health > Migrate Q10 - For Heart Health
 

 

Migrate Q10 Capsules

Not just Co-Q10, A clinically proven combination for Heart Health

Migrate Q10 Capsules - High Absorption Co-Q10 with Piperine advantage

Key Ingredients:

Each capsule contains (Halal Certified)

·         Co-enzyme Q10  100 mg

·         Lycopene 5000 mcg

·         L - Arginine 100 mg

·         Selenium 70 mcg

·         Zinc 22 mg    &  Piperine 5 mg

Coenzyme-Q10

We’re certainly hearing a lot about the nutritional supplement, Coenzyme Q10 (CoQ10). The clinical application of CoQ10 has now been validated in many clinical studies in conditions which includes coronary heart disease, heart failure, Infertilty & others

What is Coenzyme-Q10?

Co-Q10 is found in virtually every cell in the body, where it plays a pivotal role to convert fuel into energy. CoQ10 also serves as one of the body’s most crucial Antioxidant, protecting every cell against the damaging effects of free radicals. So it’s no wonder CoQ10 is receiving so much attention.

Coenzyme Q10, acts as an important cofactor in the human body for three large enzyme systems that are responsible for 90 percent of cellular energy production.

The Co-Q10 & Heart Connection 

Your heart uses more energy than any other tissue in your body, and it also typically has the highest concentration of CoQ10 to keep it operating most efficiently. The heart, therefore, is extremely sensitive to CoQ10 deficiency.

Co-Q10 Deficiency

 

 

By Age 50, Your CoQ10 Levels May Be Critically Low

After the age of 30, natural levels of CoQ10 begin to diminish. By the age of 50 this depletion of CoQ10 continues to accelerate and by age 70, your natural CoQ10 levels may be 50% lower than they were when you were a young adult![3]   

We all know that as we age, our bodies do not perform as well in certain areas. CoQ10 is one tool that enables us to fight back against aging, and provide our bodies with a nourishing antioxidants that it is struggling to produce. 

However, age isn’t the only factor that accelerates the loss of CoQ10. You might have heard that drugs especially statins can decrease the level of Co Q10.

Statins (Cholestrol Medications) depletes Co-Q10 Level

If you are taking a cholesterol-lowering statin drug such as Atrovastain, then you’re probably trying your best to stay on top of your cardiovascular health. Statins, while good in reducing cholestrol, has some side effects such fatigue, muscle pain, liver enzyme elevation etc. It is widely known that statins severely deplete your body’s natural levels of CoQ10, which can lead to issues of Co-Q10 difficiency. A Columbia University study found that within 30 days, your levels of CoQ10 can be decreased by half!

It’s more important than ever to supplement with CoQ10 so you can be sure your body has the necessary levels needed for proper cellular energy function and a strong cardiovascular system.

 

 



















Co-Q10 supplementation

A simple way to protect yourself from oxidative stress and disease 

Supplementing Coenzyme Q10 daily will make a difference,  promises a diverse range of health benefits. It claims that within a few days, users will notice all of the following benefits:
— A Marked Improvement In Cardiovascular Functionality
— 
More Energy And Stamina Throughout The Day
— 
Increased Mental Clarity And Better Cognitive Functionality
— Fewer Aches And Pains
— 
Reduced Signs Of Aging And Smoother, Younger-looking Skin

Cardiac Benefits

The heart acts like a pump, moving blood throughout the body. CoQ10 works to lessen problems associated with congestive heart failure by physically improving the heart’s pumping capability. Those suffering from congestive heart failure typically exhibit lowered levels of CoQ10 – suggesting that supplementing with CoQ10 could be a critical strategy for safeguarding cardiac health. Patients undergoing treatment with CoQ10 find they can dramatically reduce their reliance on synthetic medications, many of which may have negative side effects.
A study of 126 heart failure patients over the course of six years not only underscored the important of optimal levels of CoQ10, but shed light on the impact of statins on reducing CoQ10 to dangerous levels. 
 Great news for heart patients: Science proves that CoQ10 saves lives

 A scientific study, initiated in 2003, involved only the most severe cases of heart failure – classified by the New York Heart Association as class III or IV.  Even though they continued to take prescription medication, the patients were split into two groups; one received 100 mg of CoQ10 and the other got a placebo daily.

The patients were followed for 2 years.  After only 3 months of CoQ10 supplementation, the researchers noticed a trend toward lower levels of proBNP – a marker of heart failure severity that is released from over-worked heart muscle tissue. In just two years, the CoQ10 supplement group improved their heart failure status much better than the placebo group.

And, here’s the most important finding of this study: Only 14% of the heart patients, in the supplemented group, had a major heart event (defined as unplanned hospitalization for worsening heart failure, death from a cardiovascular cause, urgent heart transplantation, or artificial mechanical heart support).  Plus, 25% of those in the placebo group had a major cardiac event – which indicates that the untreated group of patients had twice the risk of a major cardiac event! Note: This study was the first ever to show that CoQ10 supplementation in advanced heart failure improves survival, while slashing hospitalization rates 

Co-Q10 Supports Blood Pressure naturally: Because of CoQ10’s energizing properties, it assists in lowering the oxygen demands of the heart, improving the heart’s energy efficiency and supporting healthy blood pressure.

Co-Q10 Helps in the Recovery after heart problem:  In a worldwide study conducted with 420 patients with severe heart failure, CoQ10 proved to cut the risk of a major adverse cardiovascular event after heart failure in half and decrease the risk of dying from all causes by half during the 10-year double-blind trial

 

Ref: Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Ochsner J. 2010 Spring; 10(1): 16–21. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction

 

 
 













Lycopene

Lycopene — a carotenoid antioxidant that gives fruits and vegetables like tomatoes and watermelon a pink or red color — is one nutrient you’ll want to be sure you're getting enough of it. Lycopene's antioxidant activity suggested to be more powerful than other carotenoids such as beta-carotene, and research has even revealed it may significantly reduce risk of major events like CV diseases & Stroke

The 2012 analysis followed over 1,000 men in their mid-40s to mid-50s for more than 12 years, they found that men with the highest blood levels of lycopene were 55 percent less likely to have a stroke than those with the lowest.

Hardening of the arteries (atherosclerosis):    Evidence shows that higher lycopene blood levels is associated with a reduced risk of hardening of the arteries. There is also evidence that higher lycopene blood levels can reduce the risk of heart disease associated with hardening of the arteries.

 Men with the highest concentrations of Lycopene in their adipose tissue biopsy had a 48% reduction in risk of myocardial infarction when they were compared with men with the lowest adipose lycopene concentrations

Ref:  Kohlmeier L, Kark JD, Gomez-Gracia E, et al. Lycopene and myocardial infarction risk in the EURAMIC study. Am J Epidemiol 1997;146:618–26.    http://articles.mercola.com/sites/articles/archive/2014/06/28/lycopene-tomato-pill.aspx#_edn3  

 L-Arginine

L-Arginine is an amino acid,  received a lot of interest in the medical field recently as clinical evidence shows it improves cardiovascular health

L-Arginine converts to Nitric Oxide and helps to relax the arterial walls and improve blood pressure. Nitric Oxide has been found to help prevent blood clots that cause strokes and heart attacks.

It promotes normal blood vessel dilation and reduces endothelial dysfunction and improves functional status in patients with coronary issues. 

The amazing benefits of l-arginine extend broadly for both cardiovascular and overall health, including:

  • Lowering blood pressure;
  • Reducing blood stickiness in patients with high cholesterol; 
  • Improving blood flow in those with significant coronary artery disease; 
  • Reducing symptoms associated with claudication (pain, usually in the extremities due to a lack of blood flow); 
  • Relieving congestive heart failure and improved stamina; 
  • Stabilizing angina

Ref: 1996 Circulation, AHA,  Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients With Heart Failure

 

Selenium 

Selenium has excellent antioxidant properties,plays a part in chemical reactions that stop free radicals from damaging cells and DNA. 

Studies show selenium may play a role in heart heath. Selenium reduces inflammation and prevents platelets — a type of clotting cell in the blood — from aggregating, which is necessary for blood clots to form. Blood clots can lead to stroke, heart attacks, kidney failure, pulmonary embolism and other problems.

A selenium deficiency may make atherosclerosis (a hardening of the arteries) worse, according to the University of Maryland Medical Center. Animal studies have shown supplementing selenium after a long dietary deficiency reversed cardiovascular damage in mice. Some observational studies, where doctors track people but don't randomly assign them to taking a supplement or a placebo, found that the lower the selenium levels in the blood, the higher a person's risk of high blood pressure and coronary heart disease. 
 
In one clinical trial, researchers assigned more than 450 older adults to take either a placebo or various strengths of selenium supplements for six months. They found the people taking selenium supplements had lower levels of bad cholesterol, and the group taking the highest amount of selenium (300 micrograms) also showed higher levels of HDL ("good") cholesterol, according to a May 2011 paper in the Annals of Internal Medicine.

 Ref: 2015 http://www.livescience.com/43566-selenium-supplements-facts.html

 Zinc

Zinc is an important mineral required for countless reactions and functions in the body, including proper growth and immune function, DNA synthesis, cell division and cellular metabolism. The highest concentrations of zinc in the body are found in the liver, pancreas, kidney, bone, muscles and eyes.

Zinc levels tend to decline with age, just as the risk for cardiovascular diseases increases.[1] Some of the well-known consequences of zinc deficiency are a compromised immune system, increased susceptibility to infection.[2]
Researchers believe that decreased zinc levels might increase your risk for cardiovascular disease.[3] Studies have found that zinc levels are often significantly lower in people with conditions like atherosclerosis, coronary artery disease, angina, and cardiac ischemia (reduced blood flow to the heart).[1,2,3,4,5] In one study, a higher rate of cardiac failure was found in patients who were zinc deficient.[4]
So how, exactly, does zinc protect your heart? Zinc is involved in many enzymatic reactions, cellular signaling mechanisms, and other essential functions in the cell.[6] And although it is not an antioxidant itself, zinc can exhibit antioxidant effects indirectly through the activation of other molecules.[2,6]
Low zinc levels are associated with comprised antioxidant defenses that normally protect the heart, leading to a susceptibility to oxidative stress.[3,6] Zinc deficiency is also associated with cell death (apoptosis) in heart tissues, as zinc normally suppresses apoptosis.[2,3] Zinc supplementation is, therefore, an effective way to protect the heart from injury.[6]

Piperine

Increses absorption of Coenzyme-Q10 by more than 30% (1)

Piperine is a naturally occurring compound of black pepper (Piper nigrum Linn) and long pepper (Piper longum Linn) [1] and is one of the most widely used among spices.
It has been shown that piperine can dramatically increase absorption of selenium, Coenzyme-Q10 and beta-carotene as well as other nutrients. Piperine favorably stimulates the digestive enzymes of pancreas which enhances the digestive capacity and significantly reduces the gastrointestinal food transit time. The results of clinical studies of piperine with drugs indicate that piperine administered significantly increase serum drug levels by reducing the clearance of drugs, from natural or synthetic source. The mechanisms by which piperine increases the absorption may involve increased gastrointestinal blood supply postulated thermogenic properties and the increase in bioenergetic processes. Piperine can also attenuate free radicals and reactive oxygen species and has been shown to protect against oxidative damage in vitro.

 Ref: 

  1. Badmaev, Vl“Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.” The Journal of Nutritional Biochemistry 11.2 (2000): 109-113.
  2. Brewer, M. S. “Natural antioxidants: sources, compounds, mechanisms of action, and potential applications.”Comprehensive Reviews in Food Science and Food Safety 10.4 (2011): 221-247

 For Further Details on Migrate Q10: 

Please talk to your Doctor or Haldane Pharmaceuticals Pte Ltd
Email:  enquiry@haldnepharma.com ,  Tel: (65) 6333 0063

 

 

 

 





























   
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