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Bone Health > Ensame 200 For Arthritis
What is Osteo Arthritis?
Arthritis is one of the most common chronic medical conditions encountered with older age, and osteoarthritis (OA) is the most common type of arthritis, and a major cause of disability. OA of the knee is more common than any other joint. Symptoms include pain, stiffness, and decreased range of motion. Subjects often become limited in their activities and quality of life, due to pain.
Limitations on current Treatments:
To manage the symptoms of OA,  healthcare providers often resort to multiple approaches, which include lifestyle modifications, medications, exercise or surgery. Non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay medications used to manage osteoarthritis pain. NSAIDs prevent inflammation and control pain by blocking cyclooxygenase (COX-1 and COX-2 enzymes) but their side effect profile is not always acceptable, particularly among the elderly. Each year more than 100,000 subjects are hospitalized for gastrointestinal complications of NSAIDs, and of those approximately 15% die from these complications 
Millions of people suffering from Osteo-Arthritis, should know about the latest effective treatment option called SAMe.  Supplement of this naturally occurring substance have been found to combat osteoarthritis very effectively and safely.

enSAMe 200 Tablets


SAMe (S-Adenosyl L-Methionine)  - 200mg

Mecobalamin -   500mcg

L-Methyl Folate -500mcg


What is SAMe?

S-adenosyl methionine (SAMe), a naturally occurring sulphur-containing physiologic compound synthesized in the body from amino acid L-methionine and adenosine triphosphate (ATP).  SAMe is needed for many important bio-chemical reaction in the body, which includes managing joint health. With aging or due to certain disorders the level of SAMe  comes down in the body which leads to issues including poor methylation cycle which will affect areas like  joint health and others. 


How Ensame 200 works?

Clinical studies on osteoarthritis has proven that  SAMe increases the number of chondrocytes (cartilage cells) and proteoglycans (protein). This suggests that SAMe treatment may reverse the underlying process of osteoarthritis by stimulating cartilage to grow. Cartilage acts like a spongy cushion where bone meets bone at the joint.  In osteoarthritis, this cushion gradually disintegrates.

The other main component of the joint is synovial fluid, which acts as a lubricant. The cancer-killing cytokine, TNF, has been found in the synovial fluid of people with rheumatoid arthritis, and it plays a role in bone and cartilage destruction. As mentioned above, it was recently discovered that SAMe reverses the damaging effects of TNF.

 Clinical Studies with SAMe

Many clinical trials performed in Europe and  in the United States have concluded that SAM-e is as effective as NSAIDs in reducing pain and improving functional limitations in osteoarthritis patients. There also appeared to be fewer adverse effects with SAM-e than with NSAID use.

In meta analysis of 11 studies it is shown that  S-Adenosylmethionine (SAMe) is as effective as NSAIDs in offering pain relief and improving functional limitation with less risk of side effects.

When compared with placebo, SAMe improved functional limitations of osteoarthritis

The tolerability of SAMe was similar to that of placebo and greater than that of NSAIDs



As Prescribed by the Physician  (or) as below

  • First 1-2 months - 600 to 800 mg (3 to 4 tablets) in divided dose
  • From 3rd month- 1-2 Tablets/day



ENSAME 200 is currently available in Clinics only, Please talk to your physicians

For more information please call your Haldane Pharma office or email :, Tel: (65) 6333 0063


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