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Cogen Plus Sachets

Protect your cartilage to protect your future. 

Cogen Plus is a breakthrough therapy in osteoarthritis management that uses Type II hydrolyzed collagen (marine) and functional ingredients to:

  • Protect cartilage
  • Improve cushioning and lubrication
  • Reduce pain and inflammation

Current treatments used for osteoarthritis only manage symptoms and do not slow the progression of the disease. NSAIDs are commonly used and have good effects on pain-relief and restoring joint mobility but long-term use of NSAIDs is associated with significant cardiovascular and gastric side effects.

Therefore, Cogen Plus is a safe and effective product that repairs the cartilage, relieves pain and improves mobility for osteoarthritis patients.


What is osteoarthritis?

As the most common form of arthritis, osteoarthritis impacts millions of individuals worldwide.

When the protecting cartilage that cushions the ends of the bones wears down over time, pain and discomfort may inhibit one’s ability to move, decreasing their quality of life.

Osteoarthritis is most common around the joints in your hands, knees, hips, and spine.


Symptoms of osteoarthritis:

Over time, symptoms of osteoarthritis often worsen. Osteoarthritis often results in:




Loss of flexibility

Grating sensation

Bone spurs


Causes of osteoarthritis:

Since cartilage is naturally a firm yet slippery tissue that prevents bone-on-bone friction, overuse may cause the cartilage to wear down, causing osteoarthritis. This will then cause the bone-on-bone interaction that incites pain within the individual during movement.

In addition to the breakdown of cartilage, osteoarthritis affects the entire joint by catalyzing changes in the bone structure and deterioration of the connective tissues holding the body’s structure together. Inflammation of the joint lining may also occur.


Risk factors of osteoarthritis:

Factors that may increase one’s risk of developing osteoarthritis include:

Older age:

With older age, the cartilage has been used more, therefore, leading to a higher chance of wear-and-tear.


Women are more likely to develop osteoarthritis than men.


By carrying more body weight, there is more pressure and friction on the cartilage, leading to a greater risk for osteoarthritis.

Joint injuries:

Injuries can increase one’s chances for osteoarthritis.

Repeated stress on the joint:

Some sports or jobs may require great movement, leading to additional stress on the cartilage present between bones.

Genetic linkages:

Some individuals are more genetically prone to developing osteoarthritis.

Bone deformities:

Some individuals are born with deformed joints or cartilage.

Some metabolic diseases:

Diabetes may contribute to osteoarthritis.


The Importance of Collagen:

Forming up to 90% of total bone mass and holding together all living tissue, collagen is the most abundant protein in the human body. It provides the infrastructure of our musculoskeletal system making it crucial for mobility. Highly digestible and bioavailable, collagen peptides are the result of a gentle enzymatic process that converts large, native collagen molecules into small bioactive peptides. Often referred to as Hydrolyzed Collagen, the peptides are characterized by a unique combination of 18 key amino acids and offer exceptional nutritional properties not found in other protein sources.

Collagen fibers make up between 70% and 95% of cartilage and are responsible for its structure and strength. In healthy joints, the cartilage matrix composition is regulated by chondrocytes (joint cells) through a finely balanced process of synthesis and turnover, which ensures joint lubrication and cartilage matrix renovation.

During osteoarthritis, processes are disrupted, causing an imbalance involving matrix-degrading enzymes, which attack aggrecan and collagen, resulting in a deterioration of cartilage structure and function.

Product Ingredients & Benefits:

Cogen Plus is a complete multi-factorial formula for joint function and mobility that works to help:

Lubricate joints

Reduce pain

Decrease inflammation

Protect cartilage

Improve joint function

As a comprehensive formula to help individuals struggling with osteoarthritis, Cogen Plus contains Hydrolyzed Type II Marine collagen which provides greater collagen absorption into the bloodstream. Type II collagen is also the main collagenous component of cartilage, which plays a key role in cushioning our joints.

The collagen derived from marine sources has a greater bioavailability compared to other collagen sources. Other important natural ingredients in Cogen Plus include:

  • Glucosamine:
    • Important role in synthesis of glycosaminoglycans and glycoproteins, which are essential for may parts of the joints.
  • Chondroitin Sulphate:
    • Essential component of the cartilage: gives cartilage elasticity and helps it retain water
    • Anti-inflammatory properties
    • Prevents breakdown of cartilage and stimulates repair mechanisms
    • Slows down joint space narrowing
  • Methylsulfonylmethane:
    • MSM protects cartilage through suppressing pro-inflammatory cytokines which are involved in the destructive process of cartilage extracellular matrix
  • Hyaluronic Acid:
    • Major component of the synovial fluid
    • Helps to lubricate the joints
    • Has been proven to be absorbed orally
    • Significantly improves synovial effusion and muscle strength

Cogen Plus has anti-inflammatory and analgesic ingredients for effective symptom relief, including:


Boswelia Extract

Omega 3

Zingiber Officinela


Vitamin C


Key Ingredients:

Collagen Hydrosylate (Type 2), Glucosamine, Chondroitin, MSM, Boswellia, Curcumin, Capsaicin, Zingiber, Vitamin C, Piperine


Cogen Plus is only available in select clinics.

Cogen Plus is a dietary supplement, and is therefore not intended to treat or cure any disease.

Please talk to your Doctor or Call Haldane Pharmaceuticals at (65) 6333 0063 for more information.



Please contact your Doctor or Haldane Pharmaceuticals Pte Ltd
Email: , Tel: (65) 6333 0063
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