Don’t let anxiety or stress disturb your sleep.

Daily life is busy, but a productive day starts with a good night’s sleep.

Busy people often struggle to switch “off” at night, making it difficult to achieve the good quality, restorative sleep you need.

Zenidra’s extended release capsules combine natural ingredients including valerian root and lemon balm extracts to help you fall asleep fast and wake up refreshed.

 

What are sleep disorders?

Several psychological issues can cause insomnia, but stress is the number one reason people report a lack of sleep.

Many circumstances can cause insomnia, including work, family stress, panic, poor sleep hygiene, illness, drug side effects, chronic pain, restless legs syndrome, or sleep apnea.

1 in 3 individuals suffer from sleep disorders.

Sleep disorders are defined by conditions that restrict or prevent one from sleeping. As a result, someone who suffers from a sleep disorder often experiences sleepiness during the day, greatly affecting one’s quality of life. The overall health, safety, and wellbeing of an individual is also impacted by sleep disorders. 

Common types of sleep disorders include:

• Insomnia
• Sleep apnea
• Restless legs syndrome (RLS)
• Narcolepsy

What is insomnia?

Insomnia refers to the sleep disorder that causes one to have trouble falling or staying asleep. As a common sleep disorder, insomnia has a reported rate of around 15% of people.

Short-term (acute) and long-term (chronic) insomnia are two conditions of insomnia. 

Types of insomnia:

Primary insomnia:

The presence of the sleep disorder is not linked to any previous health condition or problem.

Secondary insomnia:

Insomnia is caused by a previous health condition such as asthma, depression, arthritis, cancer, or heartburn. In addition, secondary insomnia may be linked to medication or substance use such as alcohol. 

Other types of insomnia may include:

• Sleep-onset insomnia: Refers to struggling with going to sleep.

• Sleep-maintenance insomnia: Occurs when one has trouble staying asleep during the night or frequently waking up too early. 

• Mixed insomnia: Defined by the inability or struggle with falling asleep and staying asleep during the night. 

• Paradoxical insomnia: Caused by one’s underestimation of the amount of time that has passed since they fell asleep. Therefore, it feels like they have slept for a lot less time than they actually did. 

Insomnia often results in socio-occupational impairments due to the lack or absence of sleep at night. 

 

Symptoms of sleep disorders:

The most common symptom of sleep disorders is the inability to fall asleep at night, however being very sleepy during the daytime. As a result, people with sleep disorders often fall asleep at inappropriate times during the day, including while operating a motor vehicle.

Other symptoms may include:

• Fatigue
• Issues with concentration or memory
• Unusual breathing patterns
• Grumpiness
• Sudden urge to move as your body is finally falling asleep
• Unpleasant experiences or movements during sleep

 

Causes of insomnia:

Primary causes of insomnia include:

• Stress
• Surroundings including noise, light, or temperature
• Alterations to sleep schedule or patterns including jet lag
• Genetic linkages

Secondary causes of insomnia include:

• Mental health issues including depression and anxiety
• Medications for colds, allergies, depression, high blood pressure, and asthma
• Caffeine, tobacco, or alcohol usage
• Hyperthyroidism and other endocrine problems
• ADHD
• Pregnancy
• Alzheimer’s disease
• Other sleep disorders such as sleep apnea or RLS
• PMS and menopause

 

Insomnia Risk Factors:

Some individuals are at a higher risk for insomnia than others. Statistically, insomnia affects more women than men and more older individuals than younger people. 

Other risk factors may include:

• Long-term illness
• Mental health issues
• Working rotating shifts or night shifts

 

Product Ingredients & Benefits:

Zenidra tablets were developed using the concept of Phytovitality, a patented technology based on microgranules that protect 96% of plant’s active ingredients to facilitate targeted release.

Time-release technology extends the availability and benefits of the ingredients throughout the night from the time one falls asleep by releasing ingredients at target timings for continuous sleep.

Zenidra contains 3 natural herbs that are safe and effective in improving sleep naturally.

• Valerian extract (Valeriana officinalis):
  • Helps one with difficulty sleeping along with restlessness, nervousness, and anxiety.
• Lemon balm extract (Melissa officinalis):
  • Soothing herb that helps to aid insomnia and other sleep disorders.
• Hops (Humulus lupulus):
  • Traditional medicine used in Europe that aids with the relief of insomnia, excitability, and specifically restlessness associated with nervous tension, headache and/or indigestion.

Zenidra’s combination of specific standardized extracts of Valerian (Valeriana offinalis), lemon balm (Melissa officinalis), & Hops extract works in synergy to naturally improve sleep quality and promote relaxation.

Several clinical studies have shown the beneficial therapeutic effect of a combination of Valerian and lemon balm extracts for quality of sleep and anxiety.

The sequential formulas for a synergistic action of components which enable balance to be restored in the body are catalyzed by 100% natural active ingredients with the use of quality titrated dry extracts.

The microgranules present in Zenidra provide gastroprotection, quickly passing through the intestine, and a controlled release of active ingredients with increased exchange surfaces.

How Zenidra Works:

• Zenidra increases the levels of gamma aminobutyric acid (GABA) in the brain, which is known for producing a calming effect.
• Its method of action is very similar to benzodiazepines, however Zenidra binds to the beta subunit on the GABA-A receptor
  • This leads to a hyperpolarized state when the major inhibitory neurotransmitter, GABA, binds to the GABA-A receptor.
• Valerian decreases the removal or metabolism of GABA, allowing GABA to stay around longer.
• Studies show that Valerian has an effect on GABA and glutamate receptors located in the space between neuronal cells in the brain, contributing to the overall reduction of glutamate levels, and increased availability of GABA in the brain.
• Hops lowers body temperature, allowing for sedative effects and bringing about drowsiness.

 

 

 

Product Indication:

Zenidra supports sleeping disorders as an antioxidant therapy and is available in Selected Clinics in Singapore.

Zenidra is a supplement, not intended to treat or cure diseases.

PLEASE CONTACT YOUR DOCTOR OR HALDANE PHARMACEUTICALS PTE LTD FOR FURTHER DETAILS REGARDING PRODUCT ADMINISTRATION