SAMe is a molecule that plays a crucial role in various metabolic processes, including the synthesis of glutathione, a powerful antioxidant that protects the liver from damage. It’s also a key methyl donor, essential for many cellular functions. 

• Glutathione Synthesis: SAMe is a precursor for cysteine, one of the three amino acids that make up glutathione. By supporting glutathione production, SAMe may help protect the liver from oxidative stress and damage. 
• Methylation: SAMe is involved in methylation reactions, which are important for various cellular processes, including DNA and protein synthesis. 
• Liver Damage: Studies suggest that SAMe may help normalize liver enzyme levels and reduce liver fat content in conditions like non-alcoholic fatty liver disease. 
• Alcohol-Induced Liver Injury: SAMe has been shown to be useful in opposing oxidative stress and alcohol-induced liver injury. 
  

  SAMe and Liver Diseases:

  • Chronic Liver Disease: SAMe synthesis is often depressed in chronic liver disease, making SAMe supplementation potentially beneficial. 
  • Alcoholic Liver Cirrhosis: Studies have shown that SAMe treatment can improve survival rates and delay the need for liver transplants in individuals with alcoholic liver cirrhosis.