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Rotozyme Tablets
Novel Therapy For Inflammation, Swelling, Edema & Pain

Inflammation is our body’s response to infection and injury and is part of the healing process. Inflammation is a medical term that refers to a host of complex physiologic processes mediated by the immune system.
Inflammation gets its ancient name from the obvious physical signs of inflammation: redness, heat, pain, and swelling.
In addition to being a response to injury and disease, the cellular and chemical responses of inflammation can cause disease. For example, in asthma and food allergies elicits a harmful type of inflammation. Coronary heart disease, the biggest killer of Americans, is believed to have a significant inflammatory component. 
Systemic Enzymes for Inflammation
Controlling Inflammation with Systemic Enzymes
Enzymes are the unsung heroes of the body – without them life would be impossible. It has been estimated that the human body contains at least 50,000 different enzymes that orchestrate the countless biochemical reactions that control all life functions.
Enzymes also play an essential role in inflammation and other functions of the immune system. Inflammation is one of the body’s most important mechanisms for protecting itself against danger. If you’ve ever had an insect bite, a sprained ankle, a sore throat, or a bad sunburn, you know what inflammation is. Inflammation is the body’s way of imposing a measured, temporary discomfort in the interest of long-term health. The five cardinal symptoms of inflammation are:
1.   Redness
2.   Heat
3.   Swelling
4.   Pain
5.   Restriction of Movement
These signs indicate that the body is bringing in more blood and immune resources, like white blood cells and macrophages, to remove microorganisms and other foreign matter. Redness is a sign that vasodilation is allowing more blood and other fluids to reach the affected area; local heat reflects the increased flow of warm blood from deep within the body; swelling (edema) is caused by the local accumulation of fluids; pain and restricted mobility arise from the added pressure due to the swelling.
Systemic enzymes play an essential role in inflammation and other functions of the immune system. Inflammation is one of the body’s most important mechanisms for protecting itself against danger. Proteolytic enzymes modulate the inflammatory process by a variety of mechanisms, including reducing the swelling of mucous membranes, decreasing capillary permeability, and dissolving blood clot-forming fibrin deposits and microthrombi.
* Anti-inflammation; Systemic enzymes act as the first line of defence against inflammation and play an important part in pain relief. They also aid quick recovery from sports and other injuries

* Anti Fibrosis; Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue that occurs as part of a reparative or reactive process. Systemic enzymes effectively eat scar tissue and fibrosis

* Blood Cleansing; Fibrin is a fibrous protein that is involved in the clotting of blood. When there is an excess of fibrin, blood can become thick and sticky. The risk of blood clots forming increases and that’s bad news because blood clots are one of the leading causes of strokes and heart attacks. Systemic enzymes eat up excess fibrin and in doing so improve circulation and reduce the risk of experiencing a catastrophic cardiovascular event

* Immune System Modulating; Systemic enzymes seek to keep the immune system balanced. If the immune system is low, enzymes act to improve immunity by increase immune response, producing more ‘Natural Killer’ cells, and improving the efficiency of the white blood cells. If the immune system is overactive, enzymes will seek to calm everything down by eating up excess antibodies
* Virus Fighting; Systemic enzymes are capable of recognising the difference between proteins that should be in the body and those that are foreign (should not be there like the proteins found in the cell walls of viruses). They can help to combat viral infections by attacking viruses
  Systemic Enzymes versus Anti-Inflammatory Drugs
Italian researchers have shown that the ability of proteolytic enzymes to reduce inflammation is equal to or superior to four powerful steroidal and non-steroidal anti-inflammatory drugs: Phenylbutazone, Hydrocortisone, Indomethacin, and Acetylsalicylic Acid.
Drugs like Aspirin, Ibuprofen, Celebrex, Vioxx and the rest of the Non Steroidal Anti Inflammatory Drugs all work by keeping the body from making all CIC's (Circulating Immune Complex). This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestine and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5).
Introducing Rotozyme Tablets
The Natural Anti-inflammatory 
Rotozyme is a combination of proteolytic enzymes Trypsin and Bromelain with Antioxidant Rutoside, is a synergistic combination of systemic enzymes & phytonutrient. It helps to support body’s natural anti-inflammatory action to control pain, inflammation and speed up the healing process.
This combination act as a natural anti-inflammatory, anti-oedematous, analgesic, antithrombotic, antiplatelet, antiphlogistic, immunomodulator, fibrinolytic agent.
Rotozyme contains
Trypsin       72mg
Bromelain  135mg
Rutoside    150mg
Rational for the Rotozyme combination of Bromelain, Trypsin and Rutoside:
Because of the adverse effects of NSAID’s, alternative drug therapy should be sought. Enzyme treatment provides this safe and effective alternative approach. This enzyme preparation has been proven to have a marked anti-inflammatory effect in many clinical studies and used widely to treat pain, inflammation and wound healing around the world.
The combination of both Bromelain, trypsin is logical as the different enzymes do have different substrate specificities. There is a variety of effects which are thought to contribute to their clinical efficacy such as anti-edematous effects and effects on anti-proteinases and α2 macroglobulin.
Rotozyme works by producing substances which fight against pain, inflammation and swelling. It induces migration of neutrophils at the site of acute inflammation that helps in decreasing inflammation in colonic regions; Rutoside trihydrate causes inhibition of Vascular Endothelial Growth Factor (VEGF) which helps to reduce oxidative damage and angiogenesis.
Systemic enzyme therapy intervenes in four different processes: the release of inflammatory mediators, the modulation of adhesion molecules, the dissolution of detritus and the activation of fibrolysis with consequent improved healing. Additionally, enzymes reduce immune complexes, which play a role in the pathogenesis of inflammatory rheumatic diseases. Thus, healing is accelerated.
The tolerability of Rotozyme (Bromelain, trypsin and Rutoside) is rated as very good
Rotozyme Uses:
Rotozyme tablets helps in conditions and symptoms such as:
Pain, Inflammation, Edema in post tramautic, Post-operative period
Vascular diseases like
post thrombophelbitis
Skin burns
Sinus inflammation after surgery or injury
Muscle relaxant
Muscle contraction stimulant
Enhance the effect of the co-prescribed antibiotics        
Rotozyme can shorten recovery time after surgery. As evidenced in "Sports, Medicine and Health," enzyme therapy given before and after surgery lessens swelling, inflammation and pain. It may also prevent scarring. In some cases, less pain medication is needed. The use of Rotozyme for surgery requires a physician’s consent, as it may be contraindicated in some people who are at risk of bleeding.
Sports Injury Recovery
According to "Nutrition Applied to Injury Rehabilitation and Sports Medicine," systemic enzymes stimulate quicker healing and reduce swelling, immobility, inflammation, tenderness and pain. While it can shorten recovery time once an injury has occurred, Rotozyme is best used preventatively prior to athletic events.
Daily 1 to 2 Tablets, 2 times a day,  orally, with plenty of liquid, 30 minutes before meal or at least 2hours after meal.
Rotozyme should not be taken by individuals who are pregnant or breastfeeding, or suffering from bleeding disorders or liver damage. It also should not be taken in combination with anticoagulant drugs, including aspirin.
Availability: Rotozyme is available only in Selected Clinics in Singapore. Please talk to your Doctors about Rotozyme therapy. 
For more information, Pls call HALDANE PHARMA at (65) 6333 0063
Medical Disclaimer: We believe that the role of nutrition is important to good health, however, this web site is for informational purposes only and is not intended to be a substitute for professional medical advice. Our goal is to provide you, the seeker, with the information necessary for you to make important nutritional and self-help decisions. We strongly suggest that you share any products you decide to use with your health care professional for optimal individual health benefits. Women who are planning on becoming pregnant or who are pregnant should not take any supplements without consulting their physician first. Information and statements on this website regarding dietary supplements have not been evaluated by the Food and Drug Administration, and are not intended to diagnose, treat, cure, mitigate or prevent any disease or health condition.

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4) Celebrex article Wall Street Journal 19 April 1999.
5) No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997.
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7) Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
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