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Liver Health > EnSAMe 400



  EnSAMe 400 Tablets


  S-Adenosyl L-Methionine 400mg

    Methylcobalamin 500mcg & L-Methylfolate 500mcg  

                           Supports Healthy Liver Function

  Double the strength for Faster Results 




EnSAMe 400 Tablets  

Key Ingredient: 

S-Adenosyl L-Methionine 400 mg (SAMe or Adomet)


What Does SAMe has to do with Liver ? 

There are three major functions that SAMe is involved in the human body: Transsulfuration, Transmethylation, and Aminopropylation. The first two are critical for proper liver function.  Through the process of Transsulfuration, SAMe is converted into a compound called GLUTATHIONE, a potent antioxidant and liver detoxification agent. It is an essential compound which plays a major role in protecting hepatocytes (liver cells) from waste products that the liver removes from the blood stream. Maintaining adequate levels of SAMe is therefore critical for healthy liver function.

SAMe also works to improve phospholipids production which 
promotes better bile flow through the liver's cell membranes. Proper bile flow enables the detoxification process in the liver to function correctly.

 Why SAMe? 
Normally, the body produces enough SAMe on its own from the amino acid methionine. However, as people age SAMe levels can decrease. This can potentially cause important Liver protecting processes  to slow down, or stop performing sufficiently. Taking SAMe as a supplement may help replenish low levels, and may help the body resume its normal function. Healthy levels of SAMe can help maintain healthy liver function. 

Liver Disorders:

Different types of liver disorders include Hepatitis, Cirrhosis, Liver tumors, and Liver abscess (collection of pus), just to name a few.

Liver disease can be inherited (genetic) or caused by a variety of factors that damage the liver, such as viruses and alcohol use. Obesity is also associated with liver damage. Over time, damage to the liver results in scarring called Liver cirrhosis, which can lead to liver failure, a life-threatening condition

Research has shown that patients with ALCOHOLIC LIVER DISEASE  and other liver disorders have abnormal methionine metabolism, which depletes an important substance called SAMe (S-Adenosylmethionine)in the body.  SAMe, is a compound made primarily in the liver as a byproduct of the metabolism of the AMINO acid Methionine..Taking therapeutic doses of SAMe helps reverse that affect.  

Clinical Evidence:

There are more than 100 clinical studies have been conducted, it has been proven that SAMe has clear benefits in Liver health. 

Many Liver Physicians have been prescribing SAMe for their patients successfully for the past 10 years


As a dietary supplement in Liver disorders such as Fatty Liver, Alcoholic Hepatitis & Liver Cirrhosis.


As Prescribed by the Physician  (or) as below

For Acute Liver Disorders: 400 to 1200 mg (1 to 3 tablets) in divided dose 

For Maintenance/Prevention dose: 200 to 400 mg ( 1 to 2 Tablets ) per day

Side Effects: 

SAMe is a natural compound,  very safe to consume,  side effects are very rare. Mild GI disturbances may be noticed in rare cases. 


ENSAME 400 is currently available in selected Clinics, Please talk to your physicians about Ensame 400.

For more information:

Please call Haldane Pharma office or email :

Call:(65) 6333 0063 




This page provides general health information, it should not take the place of medical advice. We encourage you to talk to your healthcare providers (Doctor, Registered dietitian, Pharmacist, etc.) about your interest in, questions about, or use of the above product and what may be best for your overall health. 


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